Immunovirology is the integrated science of how viruses and the immune system shape each other — and the analytical framework for measuring both simultaneously, from the same sample.
Viruses don't exist in a vacuum, and neither does the immune system. Every clinically relevant question — does this drug reduce the viral reservoir? Is this vaccine generating durable immunity? How is this vector activating innate defenses? — requires reading both signals at once.
Immunovirology is the integrated science of viral-immune co-dynamics. It demands assays that can measure viral load alongside T cell activation, transcriptomic shifts alongside cytokine release — ideally from the same biological sample, at the same timepoint.
Historically, virologists and immunologists worked in separate labs on separate samples answering separate questions. That era is over. The most important programs in HIV cure, cell and gene therapy, and mRNA medicine now live at this intersection.
Every assay we run is designed to answer a biological question — not just generate data. Five analytical pillars connect into unified, multi-modal workflows that no commodity CRO can replicate.
We position transcriptomics as the explanation for what your functional assays are detecting. A cytokine spike in Luminex data? Now ask why — at the gene expression level — from the same PBMC sample.
ELISpot, FluoroSpot, multiparameter flow cytometry, cytokine multiplex (Luminex), PBMC-based cytolytic assays, dendritic cell activation, and longitudinal immune monitoring — all in-house and cross-linked.
Ultra-sensitive dPCR/qPCR, targeted short- and long-read sequencing, viral load quantification, intact proviral DNA assay (IPDA), and vector copy number — with low-input capability for precious clinical specimens.
CLIA-certified. GLP/GCP-compliant. Fit-for-purpose biomarker development. Companion diagnostic support. We generate data that regulatory reviewers can rely on for IND submissions and BLAs.
PhD-level scientific leadership delivers pathway analysis, immune gene signature scoring, and viral response gene sets — integrated across modalities into a scientific narrative, not a raw data dump.
We focus immunovirology analytics where the need is greatest and the interpretive challenge is most complex.
Cell & Gene Therapy
Host transcriptional responses to AAV and lentiviral vector transduction, innate immune activation (ISGs, type I IFN pathway), and off-target gene dysregulation are increasingly required by FDA reviewers. Our integrated molecular and immune workflows address this directly — from the same sample set that feeds your safety and efficacy readouts.
HIV & Viral Persistence
Latency reversal programs require transcriptomic readouts of reservoir reactivation. Our IPDA — developed with the Siliciano lab at Johns Hopkins — combined with bulk or single-cell RNAseq on PBMCs from HIV+ donors gives cure-program sponsors a mechanistic view of reservoir dynamics no other CRO can replicate.
mRNA Therapeutics & Vaccines
Innate immune sensing of mRNA constructs — TLR signaling, type I IFN induction, stress response genes — is a major safety and development concern. Pairing immunogenicity monitoring with RNAseq gives sponsors a mechanistic safety and efficacy package from the same PBMC samples driving your cellular immunogenicity readouts.
Immuno-Oncology
Tumor antigen-specific immune monitoring combined with transcriptomic profiling of T cell exhaustion, activation state, and MoA signatures gives I-O sponsors the mechanistic depth to explain — not just observe — clinical signals. Our low-input workflows extend this to sorted populations from scarce TIL samples.
"Empowering the Right Tests for the Right Patients."
Accelevir is a Maryland-based biotechnology company developing and enabling innovative assays for ultra-rare analytes. Founded in 2015, we've developed and commercialized complex assay workflows across virology, immunology, and genomics — supported by over $15 million in federal, state, and private funding.
Our team operates at the convergence of infectious disease, cell and gene therapy, and immuno-oncology — delivering assay science that supports discovery through clinical programs for biopharma partners worldwide.
White papers, application notes, and publications from the immunovirology research community.
Accelevir's immunovirology service is the only transcriptomic offering purpose-built to integrate with functional virology and immunology data — from the same sample, in a CLIA-certified, GLP-aligned environment.